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6 changes: 3 additions & 3 deletions content/authors/Zhibo/_index.md
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Expand Up @@ -53,9 +53,9 @@ social:
#- icon: x-twitter
# icon_pack: fab
# link: https://x.com/NKalafatakis
#- icon: google-scholar
# icon_pack: ai
# link: https://scholar.google.com/citations?user=ghKM4koAAAAJ&hl=en&oi=ao
- icon: google-scholar
icon_pack: ai
link: 'https://scholar.google.com/citations?user=2snUiIAAAAAJ&hl=en'
- icon: linkedin
icon_pack: fab
link: 'https://linkedin.com/in/zhiboli1994'
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3 changes: 2 additions & 1 deletion content/project/25-11-01-Mechanosynth/index.md
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Expand Up @@ -6,7 +6,8 @@ tags:
- Biology
date: '2025-10-20T00:00:00Z'
authors:
#- Admin
- Admin
- Zhibo
# Optional external URL for project (replaces project detail page).
#external_link: 'https://www.wwtf.at/funding/programmes/ls/LS24-038/index.php?lang=EN'

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8 changes: 8 additions & 0 deletions content/publication/2026/kaivola2026/cite.bib
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@article{kaivola2026restoring,
title={Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties},
author={Kaivola, Jasmin and Punovuori, Karolina and Chastney, Megan R and Abdo, Hind and Follain, Gautier and Mathieu, Mathilde and Joshi, Omkar and Miroshnikova, Yekaterina A and Krautgasser, Fabian and Di Franco, Jasmin and others},
journal={Nature Materials},
pages={1--15},
year={2026},
publisher={Nature Publishing Group UK London}
}
109 changes: 109 additions & 0 deletions content/publication/2026/kaivola2026/index.md
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---
title: "Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties"
authors:
- Jasmin Kaivola
- Karolina Punovuori
- Megan R. Chastney
- Hind Abdo
- Gautier Follain
- Mathilde Mathieu
- Omkar Joshi
- Yekaterina A. Miroshnikova
- Fabian
- Jasmin
- James R. W. Conway
- Sofia Held
- Fabien Bertillot
- Jaana Hagström
- Antti Mäkitie
- Heikki Irjala
- Sami Ventelä
- Hellyeh Hamidi
- Giorgio Scita
- admin
- Sara A. Wickström
- Johanna Ivaska
author_notes:

- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- ""
- "Corresponding author"

date: "2026-02-20T00:00:00Z"
doi: "https://doi.org/10.1038/s41563-025-02473-7"

# Schedule page publish date (NOT publication's date).
publishDate: "2026-03-01T00:00:00Z"

# Publication type.
# Accepts a single type but formatted as a YAML list (for Hugo requirements).
# Enter a publication type from the CSL standard.
publication_types: ["article-journal"]

# Publication name and optional abbreviated publication name.
publication: "*Nat. Mater*., no. 1 (2026): 1-15"
publication_short: ""

abstract: Increased extracellular matrix deposition and stiffness promotes solid tumour progression. Yet, the precise mechanotransduction pathways, especially in less-studied mechanically responsive cancers, remain poorly understood. Here we address this gap using patient-derived tumour cells from early (mobile, T1) and advanced (immobile, T3) stages of vocal fold cancer, the most common squamous cell carcinoma severely impacting the voice box. We reveal that vocal fold cancer progression is linked to cell surface receptor heterogeneity, a loss of laminin-binding integrins in cell–cell junctions and a flocking mode of collective cell motility. Mimicking the physiological movement of healthy vocal fold tissue with stretching or vibrations decreases oncogenic β-catenin and Yes-associated protein (YAP) nuclear levels in vocal fold cancer. Multiplex immunohistochemistry of vocal fold cancer tumours shows a correlation between the extracellular matrix composition, nuclear YAP and patient survival, concordant with vocal fold cancer sensitivity to oncogenic YAP-TEAD Hippo pathway inhibitors both in vitro and in vivo. Overall, our findings suggest that vocal fold cancer is a mechanically sensitive malignancy, and that the restoration of tumour mechanophenotype or YAP/TAZ targeting represents a tractable anti-oncogenic therapeutic avenue for vocal fold cancer.

# Summary. An optional shortened abstract.
#summary: Lorem ipsum dolor sit amet, consectetur adipiscing elit. Duis posuere tellus ac convallis placerat. Proin tincidunt magna sed ex sollicitudin condimentum.

tags:
- Microscopy
- Soft matter
featured: false

links:
- name: Supplementary information
url: 'https://static-content.springer.com/esm/art%3A10.1038%2Fs41563-025-02473-7/MediaObjects/41563_2025_2473_MOESM1_ESM.pdf'
url_pdf: 'https://www.nature.com/articles/s41563-025-02473-7.pdf'
#url_code: ''
#url_dataset: ''
#url_poster: ''
#url_project: ''
#url_slides: ''
#url_source: ''
#url_video: ''

# Featured image
# To use, add an image named `featured.jpg/png` to your page's folder.
image:
caption: ''
focal_point: ""
preview_only: false

# Associated Projects (optional).
# Associate this publication with one or more of your projects.
# Simply enter your project's folder or file name without extension.
# E.g. `internal-project` references `content/project/internal-project/index.md`.
# Otherwise, set `projects: []`.
projects:
- internal-project

# Slides (optional).
# Associate this publication with Markdown slides.
# Simply enter your slide deck's filename without extension.
# E.g. `slides: "example"` references `content/slides/example/index.md`.
# Otherwise, set `slides: ""`.
#slides: example
---