Wrong Potassium internal concentration

[SteMasoli]

Hi.

I have installed the gui and it runs without issues, so far.
I loaded an ASC morphology and than looked around to understand the various tabs.

Under "ion settings", the other default values are correct but "k" (the internal potassium concentration) has a default value of only 54.4mM.
The average concentration has been estimated to be 150mM.

https://www.nature.com/articles/s42003-018-0269-2

[thorstenhater]

Hi @SteMasoli,

thanks for this interesting find! Is this a universal result (across mammals)?

The GUI uses the values set by Arbor's neuron_parameter_defaults, which
are inherited from the NEURON simulator (many of our users come from NEURON). See here:

https://nrn.readthedocs.io/en/8.2.2/rxd-tutorials/basic-initialization.html#Option-1:-NEURON-and-NMODL-defaults

That said, this is a suggestion only, you can override them at various levels: global, cell, and per region.
Here, you can just type the value you like into the field.

Thanks again, I'll keep my eyes on Neuron, if they change their presets, we'll update ours as well.