MotilityContinuum/CITATION.cff at main · Seashell520/MotilityContinuum · GitHub

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# This CITATION.cff file was generated with cffinit.
# Visit https://bit.ly/cffinit to generate yours today!

cff-version: 1.2.0
title: >-
  Bacterial motility patterns vary smoothly with spatial
  confinement and disorder
message: >-
  If you use this dataset, please cite it using the metadata
  from this file.
type: dataset
authors:
  - given-names: Haibei
    family-names: Zhang
    affiliation: University of Chicago
    orcid: 'https://orcid.org/0009-0006-7607-4649'
  - given-names: Miles
    family-names: T. Wetherington
    orcid: 'https://orcid.org/0000-0002-2738-6164'
    affiliation: Georgia Institute of Technology
  - given-names: Hungtang
    family-names: Ko
    orcid: 'https://orcid.org/0000-0001-6250-6144'
    affiliation: Princeton University
  - given-names: Cody
    family-names: E. FitzGerald
    affiliation: Northwestern University
    orcid: 'https://orcid.org/0000-0002-1646-6214'
  - given-names: Leone
    family-names: V. Luzzatto
    affiliation: Northwestern University
  - given-names: István
    family-names: A. Kovács
    affiliation: Northwestern University
    orcid: 'https://orcid.org/0000-0002-6890-6277'
  - given-names: Edwin
    family-names: M. Munro
    affiliation: University of Chicago
    orcid: 'https://orcid.org/0000-0001-5535-5675'
  - given-names: Jasmine
    family-names: A. Nirody
    email: jnirody@uchicago.edu
    affiliation: University of Chicago
    orcid: 'https://orcid.org/0000-0002-0461-1031'
identifiers:
  - type: doi
    value: 10.5200/github.2025
abstract: >-
  In unconfined environments, bacterial motility patterns
  are an explicit expression of the internal states of the
  cell. Bacteria operating a run-and-tumble behavioral
  program will swim forward when in a ‘run’ state, and will
  be stalled in place when in a reorienting ‘tumble’ state.
  However, in natural environments, motility dynamics often
  represent a convolution of bacterial behavior and
  environmental constraints. Recent investigations showed
  that Escherichia coli swimming through highly confined
  porous media exhibit extended periods of ‘trapping’
  punctuated by forward ‘hops’, a seemingly drastic
  restructuring of run-and-tumble behavior. We introduce a
  microfluidic device to systematically explore bacterial
  motility in a range of spatially structured environments,
  bridging the extremes of unconfined and highly confined
  conditions. We observe that trajectories reflecting
  unconstrained expression of run-and-tumble behavior and
  those reflecting ‘hop-and-trap’ dynamics coexist in all
  structured environments considered, with ensemble dynamics
  transitioning smoothly between these two extremes.
  Therefore, we present a unifying ‘swim-and-stall’
  framework to characterize this continuum of observed
  motility patterns and demonstrate how bacteria employing a
  consistent set of behavioral rules can present motility
  patterns that smoothly transition between the two
  extremes. Our results indicate that the control program
  underlying run-and-tumble motility is robust to changes in
  environment, allowing flagellated bacteria to navigate and
  adapt to a diverse range of complex, dynamic habitats
  using the same set of behavioral rules.
keywords:
  - motility
  - bacterial locomotion
  - E. coli
  - microfluidics
  - microbial biophysics
  - porous media
license: CC-BY-NC-4.0
commit: 032925
version: '2'
date-released: '2025-03-29'