Native Javascript (no framework)

[Karric]

Is it possible to not use a JS framework for this?

[NathanWalker]

Yes, see this which is just TypeScript only (what is often called plain or vanilla) with no framework:
https://blog.nativescript.org/develop-visionos-apps-with-typescript/

Can be created with:

npm install -g nativescript@vision
ns create myapp --vision