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Research: replace word-art sprites with styled text headings, update content
- Row 1: "3D / puzzles" (black/teal text, replacing sprite image) - Row 2: "Faster / RNA structure / determination" (High-throughput → Faster) - Row 3: "Rational / RNA design / & videogames" (RNA → Rational) - Row 1 body: updated to mention CASP, RNA-Puzzles, Kaggle competitions - Row 2 body: "in close collaboration with expert biologists at Stanford" → "and accelerating RNA cryo-EM"
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research.md

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<p class="page-lead"><strong>Our lab strives to</strong> model and design the RNA sequences that define and regulate living systems.</p>
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<div class="research-row">
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<i class="word-research-1" aria-label="3D puzzles"></i>
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<p>We develop algorithms to predict the structures and energetics of RNAs and RNA/protein interfaces with high accuracy. We test these ideas through community-wide blind trials; by enhancing NMR, crystallographic, and cryoelectron microscopy methods; and by designing new nanostructures.</p>
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<div class="research-heading"><span class="large">3D</span><br><span class="accent">puzzles</span></div>
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<p>We develop algorithms to predict the structures and energetics of RNAs and RNA/protein interfaces with high accuracy. We test these ideas through community-wide blind trials like CASP, RNA-Puzzles, and Kaggle competitions.</p>
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<a href="https://www.pnas.org/content/108/51/20573.full" target="_blank" rel="noopener noreferrer external">
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<img src="{{ '/assets/images/site/public/img_research_puzzle.png' | relative_url }}" alt="RNA Puzzle community blind trial">
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</a>
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<hr>
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<div class="research-row">
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<i class="word-research-2" aria-label="RNA chemical mapping"></i>
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<p>Complementary to our computational research, we are developing information-rich biochemical methods to model the myriad structures of non-coding RNAs that remain unknown. Current efforts focus on probing the extent of RNA structure and conformational change inside cells and viruses, in close collaboration with expert biologists at Stanford.</p>
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<div class="research-heading"><span class="large">Faster</span><br><span class="accent">RNA structure</span><br><span class="thin">determination</span></div>
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<p>Complementary to our computational research, we are developing information-rich biochemical methods to model the myriad structures of non-coding RNAs that remain unknown. Current efforts focus on probing the extent of RNA structure and conformational change inside cells and viruses, and accelerating RNA cryo-EM.</p>
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<a href="https://www.nature.com/nchem/journal/v3/n12/full/nchem.1176.html" target="_blank" rel="noopener noreferrer external">
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<img src="{{ '/assets/images/site/public/img_research_mapping.png' | relative_url }}" alt="RNA chemical mapping">
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</a>
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<hr>
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<div class="research-row">
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<i class="word-research-3" aria-label="Designs"></i>
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<div class="research-heading"><span class="large">Rational</span><br><span class="accent">RNA design</span><br><span class="thin">&amp; videogames</span></div>
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<p>We aim to design new RNA molecules for basic science, diagnostics, and therapeutics. Our videogame project EteRNA seeks missing rules and novel molecules for medicine by giving citizen scientists access to high-throughput wet-lab experiments.</p>
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<a href="https://eternagame.org/" target="_blank" rel="noopener noreferrer external">
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<img src="{{ '/assets/images/site/public/img_research_eterna.jpg' | relative_url }}" alt="EteRNA game project">

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