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Our lab strives to model and design the RNA sequences that define and regulate living systems.
puzzles
We develop algorithms to predict the structures and energetics of RNAs and RNA/protein interfaces with high accuracy. We test these ideas through community-wide blind trials like CASP, RNA-Puzzles, and Kaggle competitions.
RNA structure
determination
Complementary to our computational research, we are developing information-rich biochemical methods to model the myriad structures of non-coding RNAs that remain unknown. Current efforts focus on probing the extent of RNA structure and conformational change inside cells and viruses, and accelerating RNA cryo-EM.
RNA design
& videogames
We aim to design new RNA molecules for basic science, diagnostics, and therapeutics. Our videogame project EteRNA seeks missing rules and novel molecules for medicine by giving citizen scientists access to high-throughput wet-lab experiments.
